Long-Term Continuous Positive Airway Pressure Therapy Normalizes High Exhaled Nitric Oxide Levels in Obstructive Sleep Apnea.
529-535.
Ai-Ping Chua, M.B.B.S1,3; Loutfi S. Aboussouan, M.D., F.A.A.S.M.1,3; Omar A. Minai, M.D., F.A.A.S.M.1,3; Kelly Paschke, B.A.2; Daniel Laskowski, B.S.3; Raed A. Dweik, M.D.2,3
BRIEF SUMMARY
Current Knowledge/Study Rationale: We perform this study to examine FENO levels in patients with OSA and the impact on these levels by CPAP therapy. Thus we hope to establish the role of FENO measurement in the assessment and control of sleep apnea.
Study Impact: This scientific work adds to the increasing knowledge on the role of upper airway inflammation in the pathophysiology and treatment of obstructive sleep apnea. It also provides further insight into the role of exhaled nitric oxide gas measurement in the diagnosis and monitoring of this common sleep condition.
Impact of Group Education on Continuous Positive Airway Pressure Adherence.
537-541.
Christopher J. Lettieri, M.D., F.A.A.S.M.1,2; Robert J. Walter, M.D., D.H.C.E.1,2
BRIEF SUMMARY
Current Knowledge/Study Rationale: Patient education regarding the effects of OSA, benefits for therapy, and proper use of CPAP are fundamental for improving both adherence to therapy and outcomes. Unfortunately, the demands for initial evaluations often impair the capacity of sleep centers to provide this service. Strategies that can enhance patient-directed education without compromising clinic efficiency are clearly needed.
Study Impact: A group educational program may facilitate both improved access to care and increased CPAP adherence.
A Pilot Study of CPAP Adherence Promotion by Peer Buddies with Sleep Apnea.
543-550.
Sairam Parthasarathy, M.D., F.A.A.S.M.1,2,3; Christopher Wendel, M.S.1,2; Patricia L. Haynes, Ph.D.1,4; Charles Atwood, M.D., F.A.A.S.M.5; Samuel Kuna, M.D., F.A.A.S.M.6
BRIEF SUMMARY
Current Knowledge/Study Rationale: Poor adherence to the primary treatment of OSA—continuous positive airway pressure (CPAP) therapy—is common, and there is a paucity of easily accessible yet cost-effective interventions that could promote CPAP adherence. Promoting adherence to therapy through peer-driven intervention is cost-effective and has met with modest success in other chronic conditions such as HIV, heart failure and diabetes mellitus, but whether such a peer-driven intervention can improve adherence to CPAP therapy is unknown.
Study Impact: Our pilot study involved such a peer-driven intervention (experienced CPAP users called “peer-buddies”) and suggests that such an intervention is feasible, results in high patient satisfaction, and promotes CPAP adherence. A larger, adequately powered study is needed, which, if successful, could potentially improve outcomes in a “patient-centered” and cost-effective manner.
Comparison of Polysomnographic and Clinical Presentations and Predictors for Cardiovascular-Related Diseases between Non-Obese and Obese Obstructive Sleep Apnea among Asians.
553-557.
Naricha Chirakalwasan, M.D.1,2; Busarakum Teerapraipruk, M.D.1,3,4; Rosalind Simon, M.D.1,4,5; Prakobkiat Hirunwiwatkul, M.D.1,4; Nattapong Jaimchariyatam, M.D.1,2; Tayard Desudchit, M.D.1,6; Natamon Charakorn, M.D.4; Chaisiri Wanlapakorn, M.D.7
BRIEF SUMMARY
Current Knowledge/Study Rationale: Majority of obstructive sleep apnea among Asians are not obese (BMI < 25) and believed to have predis-posing craniofacial structure. Differences between obese and non-obese obstructive sleep apnea groups are investigated in this current study.
Study Impact: Obese and non-obese obstructive sleep apnea among Asians appeared to have some different clinical and polysomnographic entities as well as risk factors for cardiovascular-related diseases development.
Sleep Habits, Insomnia, and Daytime Sleepiness in a Large and Healthy Community-Based Sample of New Zealanders.
559-566.
Bradley R. Wilsmore, M.B.B.S., Ph.D.1; Ronald R. Grunstein, M.D., Ph.D.1; Marlene Fransen, Ph.D.2; Mark Woodward, Ph.D.2; Robyn Norton, Ph.D.2; Shanthi Ameratunga, Ph.D.3
BRIEF SUMMARY
Current Knowledge/Study Rationale: Insomnia, daytime sleepiness and inadequate sleep are common complaints, but have not been accurately quantified in the past. The current study utilised 22,389 relatively healthy New Zealanders with the ability to control for multiple confounders such as depression, sleep disordered breathing and substance abuse, to more accurately determine how common these sleep complaints are, and to identify the relationship between such sleep complaints, primary insomnia, excessive daytime sleepiness, and lifestyle factors.
Study Impact: This study highlights how incredibly common sleep complaints are, even in this relatively young, healthy, nonclinical sample, and identifies some of the common associations such as depression, long work hours, alcohol dependence, and rotating shift work.
The Relation between Insomnia Symptoms, Mood, and Rumination about Insomnia Symptoms.
567-575.
Colleen E. Carney, Ph.D.1; Andrea L. Harris, M.A.1; Ashley Falco, B.A.2; Jack D. Edinger, Ph.D.3
BRIEF SUMMARY
Current Knowledge/Study Rationale: Insomnia-specific rumination is a process in which there is repetitive thought about the symptoms of insomnia, such as fatigue. A few studies have found that rumination in insomnia is not merely a depressive process. The current study tested an insomnia-specific rumination measure in two distinct samples, including a sample of adults with clinical insomnia, and found similar support for insomnia-specific rumination that is distinct from depressive rumination.
Study Impact: The corroboration of previous findings showing that there is rumination in insomnia, distinct from that found in depression, suggests that rumination-targeted treatments are worthy of investigation in those with insomnia.
Perceived Insufficient Rest or Sleep among Veterans: Behavioral Risk Factor Surveillance System 2009.
577-584.
Paul M. Faestel, M.D., M.P.H.1; Christopher T. Littell, D.O., M.P.H.1; Michael V. Vitiello, Ph.D.2; Christopher W. Forsberg, M.S.3; Alyson J. Littman, Ph.D., M.P.H.3,4
BRIEF SUMMARY
Current Knowledge/Study Rationale: Few prior studies have investigated whether the prevalence of sleep problems differ between Veterans and demographically similar non-Veterans. Further description of the prevalence of insufficient rest or sleep among Veterans may help to identify high-risk groups to target for interventions.
Study Impact: Veterans are more likely to report frequent insufficient rest or sleep compared to their non-Veteran counterparts. Specific subsets of this population which require particular attention when addressing this component of the clinical encounter include younger Veterans, those who are unable to work, and those who are experiencing frequent mental distress.
Total Sleep Time and Other Sleep Characteristics Measured by Actigraphy Do Not Predict Incident Hypertension in a Cohort of Community-Dwelling Older Men.
585-591.
Maple M. Fung, M.D.1,2; Katherine Peters, M.S.3; Sonia Ancoli-Israel, Ph.D., F.A.A.S.M.2,4; Susan Redline, M.D., M.P.H.5; Katie L. Stone, Ph.D.3; Elizabeth Barrett-Connor, M.D.6
BRIEF SUMMARY
Current Knowledge/Study Rationale: Studies have shown an inconsistent association between total sleep time and hypertension. This prospective study was performed to evaluate this relationship using actigraphy measured sleep variables in community-dwelling older men.
Study Impact: This study indicates that short sleep time and other indicators of poor sleep were not associated with incident hypertension in older men, which is consistent with other studies of older subjects. The effect of reduced sleep may have a greater effect in the development of hypertension in younger individuals.
Sleep Oxygen Desaturation Predicts Survival in Idiopathic Pulmonary Fibrosis.
593-601.
Likurgos Kolilekas, M.D.1,2; Effrosyni Manali, M.D.3; Katerina A. Vlami, M.D.1; Panagiotis Lyberopoulos, M.D.1; Christina Triantafillidou, M.D.1,4; Konstantinos Kagouridis, M.D.1; Katerina Baou, M.D.1; Sotirios Gyftopoulos1; Konstantinos N. Vougas, Ph.D.5; Anna Karakatsani, M.D., M.P.H., Ph.D.1; Manos Alchanatis, M.D.3; Spyros Papiris, M.D., Ph.D.1
BRIEF SUMMARY
Current Knowledge/Study Rationale: Sleep breathing disorders are frequent in idiopathic pulmonary fibrosis. The aim of the study was to examine the relationship between SBDs and clinical and functional parameters of IPF, and to evaluate the impact of SBDs on survival in IPF.
Study Impact: Our data indicate that sleep oxygen desaturation and apnea-hypopnea index affect negatively survival in IPF patients and that sleep in IPF is a process mimicking maximal exercise, arising an important question: if CPAP treatment can modify disease progression in IPF.
Sleep Duration and Reported Functional Capacity among Black and White US Adults.
605-609.
Perry Brimah, M.D.1,2; Franscene Oulds, M.D.1; Oladipupo Olafiranye, M.D.1,3; Mirnova Ceide, M.D.1; Shavon Dillon, M.D.1; Olasumbo Awoniyi, M.D.1; Joao Nunes, M.D.1,4; Girardin Jean-Louis, Ph.D.5
BRIEF SUMMARY
Current Knowledge/Study Rationale: Abnormally short and long sleep durations are associated with various chronic health conditions. However, there is dearth of evidence regarding relationships of sleep durations with functional capacity - an important clinical diagnostic and prognostic factor. Blacks may be at greatest risk of experiencing impaired functional capacity because of the higher prevalence of chronic health conditions as well as short and long sleep durations in that population.
Study Impact: Understanding of the relationship between sleep duration and functional capacity and the role of health disparities is vital to potentially modifying the determinants of sleep-related diseases. Consideration of influences of race/ethnicity is crucial in analysis of epidemiologic sleep data.
Narcolepsy with Cataplexy Mimicry: The Strange Case of Two Sisters.
611-612.
Fabio Pizza, M.D., Ph.D.1; Stefano Vandi, RPSGT1; Francesca Poli, M.D., Ph.D.1; Keivan Kaveh Moghadam, M.D.1; Christian Franceschini, Psy.D., Ph.D.2; Claudia Bellucci, Psy.D.3; Carlo Cipolli, Psy.D.3; Francesca Ingravallo, M.D., Ph.D.4; Giuliana Natalini, M.D.5; Emmanuel Mignot, M.D., Ph.D., F.A.A.S.M.6; Giuseppe Plazzi, M.D., Ph.D.1