Potential of Proteomics as a Bioanalytic Technique for Quantifying Sleepiness
Center for Sleep and Circadian Neurobiology, Division of Sleep Medicine, University of Pennsylvania, Philadelphia, PA
Currently, there are no simple ways to assess the degree of sleep loss in individual subjects. Proteins constitute greater than 98% of all molecules in the cell. They participate in physiological interactions, explain all of posttranslational modifications that occur in cellular micro-environments and thus are potential candidates for identification of a biomarker of sleepiness. A variety of proteonomic techniques are available which are being used in a current sleep deprivation study of monozygotic and dizygotic twin pairs we are performing.
Naidoo N. Potential of proteomics as a bioanalytic technique for quantifying sleepiness. J Clin Sleep Med 2011;7(5):Supplement S28-S30.
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