Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study
1Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine University of Miami, Miami, FL; 2Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY; 3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; 4Division of Social Epidemiology, Department of Health Policy, Mount Sinai School of Medicine, New York, NY; 5Department of Epidemiology and Public Health, University of Miami, Miami, FL; 6Department of Human Genetics, University of Miami, Miami, FL; 7Neuroscience Program, University of Miami, Miami, FL
Short and long sleep duration are associated with increased mortality and worse global cognitive function, but is unclear if these relations persist after accounting for the risk of sleep disordered breathing (SDB). The aim of our study is determine the association between short and long sleep duration with worse global cognitive function in a racially/ethnically diverse elderly cohort.
We examined sleep hours and global cognitive function cross-sectionally within the population-based Northern Manhattan Study cohort. We conducted nonparametric and logistic regression to examine associations between continuous, short (< 6 h) and long (≥ 9 h) sleep hours with performance on the Mini Mental State Examination (MMSE).
There were 927 stroke-free participants with data on self-reported sleep hours and MMSE scores (mean age 75 ± 9 years, 61% women, 68% Hispanics). The median (interquartile range) MMSE was 28 (10-30). Sleep hours (centered at 7 h) was associated with worse MMSE (β = -0.01; SE [0.004], p = 0.0113) adjusting for demographics, vascular risk factors, medications, and risk for SDB. Reporting long sleep (≥ 9 h) compared to 6 to 8 h of sleep (reference) was significantly and inversely associated with MMSE (adjusted β = -0.06; SE [0.03], p = 0.012), while reporting short sleep was not significantly associated with MMSE performance. Long sleep duration was also associated with low MMSE score when dichotomized (adjusted OR: 2.4, 95% CI: 1.1-5.0).
In this cross-sectional analysis among an elderly community cohort, long sleep duration was associated with worse MMSE performance.
Ramos AR; Dong C; Elkind MSV; Boden-Albala B; Sacco RL; Rundek T; Wright CB. Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study. J Clin Sleep Med 2013;9(7):669-673.
Please login to continue reading the full article
Subscribers to JCSM get full access to current and past issues of the JCSM.
Login to JCSM
Not a subscriber?
Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership