Short Duration of Sleep Is Associated with Hyperleptinemia in Taiwanese Adults
1Department of Medical Research, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan; 2Dalla Lana School of Public Health, University of Toronto, Ontario, Canada; 3Department of Allergy, Immunology and Rheumatology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan; 4School of Medicine, Tzu Chi University, Hualien, Taiwan; 5Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan
Higher plasma levels of leptin have been associated with increased cardiometabolic risk. The aim of this study was to investigate the association between short duration of sleep and hyperleptinemia in Taiwanese adults.
We examined the association between duration of sleep and hyperleptinemia in 254 men and women recruited from the physical examination center at a regional hospital in southern Taiwan. Hyperleptinemia was defined as a plasma leptin level of 8.13 ng/mL and above. Short sleep duration was defined as < 6.5 h/day. Multiple logistic regression analysis was used to assess the association between short duration of sleep and hyperleptinemia.
In females, short duration of sleep (< 6.5 h/day; OR = 2.15, 95% CI = 0.99-4.78), greater hip circumference (OR = 3.00, CI = 1.13-8.78), higher percent body fat (OR = 1.75, CI = 1.07-2.95), and higher white blood cell counts (OR = 1.67, CI = 1.26-2.28) were associated with an increased risk of hyperleptinemia. In males, greater body weight was significantly associated with an increased risk of hyperleptinemia (OR = 3.55, 95% CI = 1.46-10.23). There was also a trend of association (p = 0.096) between short duration of sleep and an increased risk of hyperleptinemia (OR = 4.98, 95% CI = 0.80-42.40).
In this study of healthy Taiwanese adults, short duration of sleep was significantly associated with hyperleptinemia in women, and the association was independent of adiposity.
Koo M; Lai NS; Chiang JK. Short duration of sleep is associated with hyperleptinemia in Taiwanese adults. J Clin Sleep Med 2013;9(10):1049-1055.
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